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SGLT2i, Topics

May 16, 2017

Invokana Boxed Warning for Lower Limb Amputations

Here is a brief preview of this blast: FDA has issued a Drug Safety Communication regarding an increased risk of lower limb amputations associated with canagliflozin therapies (Invokana, Invokamet, Invokamet XR) based on results from the CANVAS CV outcomes study. As such, FDA is requiring a Boxed Warning to be added to the labels of the respective drugs.